Charlie decided to return to work after his pulmonary embolism. Holby A&E got a new Critical Care Manager, Dan Robinson, a new Health Service Assistant Spencer, and a new staff nurse Colette Kehan.
The department was overrun by the press when Adam's HIV status got into the papers. This ended when Adam made a statement to the press and resigned.
The team were all shaken by Holly's experience when she was stalked by anaesthetist Tom Harvey. She was lured back to her flat, but managed to escape with Dan's help. Tom was arrested.
Duffy's husband Andrew Bower returned to Holby A&E as a locum, helping to cope with the extra patients as Broadway General A&E department is closed for refurbishment. Duffy, pregnant for the third time, took maternity leave.
New student nurse Anna Paul joined the team. At the end of the series Penny left to get to know her father better.
In the last episode of the series Tom returned, and kidnapped Holly. Outside, he bumped into Andrew, sho was surprised to see him. Tom gave him a shove and he fell down some stairs. He was found and taken into resusc but the team were unable to resuscitate him. Charlie had to break the news to the heavily-pregnant Duffy. Holly, however, was saved by Patrick and Dan, and Tom plunged to his death from a fire escape.